why lh surge


Luteinizing hormone - Wikipedia, the free encyclopedia

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** Luteinizing hormone **

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Chorionic gonadotropin alpha
Identifiers
Symbol CGA
Alt. symbols HCG, GPHa, GPHA1
Entrez 1081
HUGO 1885
OMIM 118850
RefSeq NM_000735
UniProt P01215
Other data
Locus Chr. 6 /q14-q21/

Luteinizing hormone beta polypeptide
Identifiers
Symbol LHB
Entrez 3972
HUGO 6584
OMIM 152780
RefSeq NM_000894
UniProt P01229
Other data
Locus Chr. 19 /q13.3/

*Luteinizing hormone* (*LH*, also known as *lutropin* and sometimes
*lutrophin*^[1]) is a hormone produced by gonadotropic cells in the
anterior pituitary gland. In females, an acute rise of LH ("*LH surge*")
triggers ovulation^[2] and development of the corpus luteum. In males,
where LH had also been called *interstitial cell–stimulating hormone*
(*ICSH*),^[3] it stimulates Leydig cell production of testosterone.^[2] It
acts synergistically with FSH.

*Contents*

· 1 Structure
· 2 Genes
· 3 Function

· 3.1 Effects in Females
· 3.2 Effects in Males

· 4 Normal levels
· 5 Predicting ovulation
· 6 Disease states

· 6.1 Excess
· 6.2 Deficiency

· 7 As a medication
· 8 References
· 9 External links

*Structure[edit]*

LH is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein
molecule; one alpha and one beta subunit make the full, functional protein.

Its structure is similar to that of the other glycoprotein hormones,
follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and
human chorionic gonadotropin (hCG). The protein dimer contains 2
glycopeptidic subunits, labeled alpha and beta subunits, that are
non-covalently associated (i.e., without any disulfide bridge linking
them):^[4]

· The /alpha subunits/ of LH, FSH, TSH, and hCG are identical, and contain
92 amino acids in human but 96 amino acids in almost all other vertebrate
species (glycoprotein hormones do not exist in invertebrates).

· The /beta


Source: en.wikipedia.org/wiki/Luteinizing_hormone

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