Fast Facts About Gout

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what is gout

Gout - Wikipedia, the free encyclopedia


** Gout **

From Wikipedia, the free encyclopedia
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"Podagra" redirects here. For the moth genus, see Podagra (moth).

/Classification and external resources/
A small creature with sharp teeth is biting into a swollen foot at the base
of the big toe
/Gout/, a 1799 caricature by James Gillray
ICD-10 M10
ICD-9 274.00 274.1 274.8 274.9
OMIM 138900 300323
DiseasesDB 29031
MedlinePlus 000422
eMedicine emerg/221 med/924 med/1112 oph/506 orthoped/124 radio/313
MeSH D006073

*Gout* (also known as *podagra* when it involves the big toe)^[1] is a
medical condition usually characterized by recurrent attacks of acute
inflammatory arthritis—a red, tender, hot, swollen joint. The
metatarsal-phalangeal joint at the base of the big toe is the most commonly
affected (approximately 50% of cases). However, it may also present as
tophi, kidney stones, or urate nephropathy. It is caused by elevated levels
of uric acid in the blood. The uric acid crystallizes, and the crystals
deposit in joints, tendons, and surrounding tissues.

Clinical diagnosis may be confirmed by seeing the characteristic crystals
in joint fluid. Treatment with nonsteroidal anti-inflammatory drugs
(NSAIDs), steroids, or colchicine improves symptoms. Once the acute attack
subsides, levels of uric acid are usually lowered via lifestyle changes,
and in those with frequent attacks, allopurinol or probenecid provide
long-term prevention.

Gout has become more common in recent decades, affecting about 1–2% of
the Western population at some point in their lives. The increase is
believed due to increasing risk factors in the population, such as
metabolic syndrome, longer life expectancy and changes in diet. Gout was
historically known as "the disease of kings" or "rich man's disease".


· 1 Signs and symptoms
· 2 Cause

· 2.1 Lifestyle
· 2.2 Genetics


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