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Crohn's disease - Wikipedia, the free encyclopedia


** Crohn's disease **

From Wikipedia, the free encyclopedia
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"Crohn" redirects here. It is not to be confused with Croan, Krone, or

Crohn's disease
/Classification and external resources/

The three most common sites of intestinal involvement in *Crohn's disease*

ileal, ileocolic and colonic.^[1]
ICD-10 K50
ICD-9 555
OMIM 266600
DiseasesDB 3178
MedlinePlus 000249
eMedicine med/477 ped/507 radio/197
MeSH D003424

*Crohn's disease*, also known as *Crohn syndrome* and *regional enteritis*,
is a type of inflammatory bowel disease that may affect any part of the
gastrointestinal tract from mouth to anus, causing a wide variety of
symptoms. It primarily causes abdominal pain, diarrhea (which may be bloody
if inflammation is at its worst), vomiting (can be continuous), or weight
loss,^[1]^[2]^[3] but may also cause complications outside the
gastrointestinal tract such as skin rashes, arthritis, inflammation of the
eye, tiredness, and lack of concentration.^[1] Crohn's disease is caused by
interactions between environmental, immunological and bacterial factors in
genetically susceptible individuals.^[4]^[5]^[6] This results in a chronic
inflammatory disorder, in which the body's immune system attacks the
gastrointestinal tract possibly directed at microbial antigens.^[5]^[7]
Crohn's disease has wrongly been described as an autoimmune disease in the
past; recent investigators have described it as an immune deficiency

There is a genetic association with Crohn's disease, primarily with
variations of the /NOD2/ gene and its protein, which senses bacterial cell
walls. Siblings of affected individuals are at higher risk.^[13] Males and
females are equally affected. Smokers are two times more likely to develop
Crohn's disease than nonsmokers.^[14] Crohn's disease affects between
400,000 and 600,000 people in North America.^[15]Prevalence estimates for
Northern Europe have ranged from 27–48 per 100,000


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