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Hepatitis B vaccine - Wikipedia, the free encyclopedia


** Hepatitis B vaccine **

From Wikipedia, the free encyclopedia
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Hepatitis B vaccine
Vaccine description
Target disease Hepatitis B
Type Subunit
Clinical data
Trade names Recombivax HB
AHFS/Drugs.com monograph
MedlinePlus a607014
Pregnancy cat.  ?
Legal status  ?
ATC code J07BC01
 N (what is this?)  (verify)

*Hepatitis B vaccine* is a vaccine developed for the prevention of
hepatitis B virus infection. The vaccine contains one of the viral envelope
proteins, hepatitis B surface antigen (HBsAg). It is produced by yeast
cells, into which the genetic code for HBsAg has been inserted.^[1] A
course of two to three (2–3) vaccine injections are given, the second
injection at least one month after the first dose and the third injection
being administered six months after the first dose. The first and second
dose offer complete protection. The final injection (second or third
depending on number of vaccines being administered) is to prolong
protection against the hepatitis B virus. ^[2] Afterward an immune system
antibody to HBsAg is established in the bloodstream. The antibody is known
as /anti-HBsAg/. This antibody and immune system memory then provide
immunity to hepatitis B infection.^[3] The first vaccine became available
in 1981.

A range of vaccines is available in the market. Presently recombinant DNA
vaccines are available, which means they are produced by inserting the gene
for HBV into common baker's yeast where it is grown, harvested, and
purified. HBV infection cannot occur from receiving hepatitis B vaccine.
The common brands available are Recombivax HB (Merck), Engerix-B (GSK),
Elovac B (Human Biologicals Institute, a division of Indian Immunologicals
Limited), Genevac B (Serum Institute), Shanvac B, etc. These vaccines are
given intramuscularly.


· 1 The invention
· 2 Recommended populations
· 3 Response

Source: en.wikipedia.org/wiki/Hepatitis_B_vaccine

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