Doxycycline - Wikipedia, the free encyclopedia


** Doxycycline **

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Systematic (IUPAC) name
3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo-
1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide
Clinical data
Trade names Vibramycin Monodox, Microdox, Periostat, Vibra-Tabs, Oracea,
Doryx,Vibrox, Adoxa, Doxyhexal, Doxylin, Doxoral, Doxy-1', Atridox
AHFS/ monograph
MedlinePlus a682063
Licence data US FDA:link
Pregnancy cat. D (AU) D (US)
Legal status Prescription Only (S4) (AU) POM (UK) ℞-only (US)
Routes oral, buccal, intravenous therapy, intramuscular injection
Pharmacokinetic data
Bioavailability 100%
Protein binding 90%
Metabolism Hepatic
Half-life 15-25 hours
Excretion Urine (40%)
CAS number 564-25-0^ YesY
ATC code J01AA02 A01AB22
PubChem CID 11256
DrugBank DB00254
ChemSpider 10482106^ YesY
UNII 334895S862^ YesY
KEGG D02129^ N
ChEBI CHEBI:60648^ YesY
Chemical data
Formula C[22]H[24]N[2]O[8]^ 
Mol. mass 444.43 g/mol



InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1^ YesY

 N (what is this?)  (verify)

Generic 100 mg doxycycline capsules

*Doxycycline* (IPA: /ˌdɒksiˈsaɪklin/) is a tetracycline
antibiotic, and is commonly used to treat a variety of infections. Under
the brand name /Vibramycin/, Pfizer's doxycycline product received US Food
and Drug Administration approval in 1967.^[1] Other brand names include
Monodox, Microdox, Periostat, Vibra-Tabs, Oracea, Doryx,^[2] Vibrox, Adoxa,
Doxyhexal, Doxylin, Doxoral, Doxy-1 and Atridox (topical doxycycline
hyclate for periodontitis).


· 1 Medical uses

· 1.1 Antiprotozoal
· 1.2 Antibacterial
· 1.3 Antihelminthic

· 2 Adverse effects
· 3 Interactions
· 4 Pharmacokinetics
· 5 Physical and chemical properties
· 6 Experimental applications
· 7 History
· 8 References
· 9 External links

*Medical uses[edit]*

Further information: Oxytetracycline

In addition to the general indications for all members



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