Doxycycline - Wikipedia, the free encyclopedia

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** Doxycycline **

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Doxycycline


Systematic (IUPAC) name
(4/S/,4a/R/,5/S/,5a/R/,6/R/,12a/S/)-4-(dimethylamino)-
3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo-
1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide
Clinical data
Trade names Vibramycin Monodox, Microdox, Periostat, Vibra-Tabs, Oracea,
Doryx,Vibrox, Adoxa, Doxyhexal, Doxylin, Doxoral, Doxy-1', Atridox
AHFS/Drugs.com monograph
MedlinePlus a682063
Licence data US FDA:link
Pregnancy cat. D (AU) D (US)
Legal status Prescription Only (S4) (AU) POM (UK) ℞-only (US)
Routes oral, buccal, intravenous therapy, intramuscular injection
Pharmacokinetic data
Bioavailability 100%
Protein binding 90%
Metabolism Hepatic
Half-life 15-25 hours
Excretion Urine (40%)
Identifiers
CAS number 564-25-0^ YesY
ATC code J01AA02 A01AB22
PubChem CID 11256
DrugBank DB00254
ChemSpider 10482106^ YesY
UNII 334895S862^ YesY
KEGG D02129^ N
ChEBI CHEBI:60648^ YesY
ChEMBL CHEMBL1433^ N
Chemical data
Formula C[22]H[24]N[2]O[8]^ 
Mol. mass 444.43 g/mol
SMILES

·
O.CN(C)[C@@H]3C(\O)=C(\C(N)=O)C(=O)[C@@]4(O)C(/O)=C2/C(=O)c1c(cccc1O)[C@H](C)[C@H]2[C@H](O)[C@@H]34

InChI

·
InChI=1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1^ YesY
Key:XQTWDDCIUJNLTR-CVHRZJFOSA-N^ YesY

 N (what is this?)  (verify)

Generic 100 mg doxycycline capsules

*Doxycycline* (IPA: /ˌdɒksiˈsaɪklin/) is a tetracycline
antibiotic, and is commonly used to treat a variety of infections. Under
the brand name /Vibramycin/, Pfizer's doxycycline product received US Food
and Drug Administration approval in 1967.^[1] Other brand names include
Monodox, Microdox, Periostat, Vibra-Tabs, Oracea, Doryx,^[2] Vibrox, Adoxa,
Doxyhexal, Doxylin, Doxoral, Doxy-1 and Atridox (topical doxycycline
hyclate for periodontitis).

*Contents*

· 1 Medical uses

· 1.1 Antiprotozoal
· 1.2 Antibacterial
· 1.3 Antihelminthic

· 2 Adverse effects
· 3 Interactions
· 4 Pharmacokinetics
· 5 Physical and chemical properties
· 6 Experimental applications
· 7 History
· 8 References
· 9 External links

*Medical uses[edit]*

Further information: Oxytetracycline

In addition to the general indications for all members


Source: en.wikipedia.org/wiki/Doxycycline


doxycycline

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